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Therefore, we propose an adaptive procedure, termed AP-SKAT, for the highly efficient calculation of SKAT statistics. This procedure adaptively stops the permutation test when the significance level is outside some predetermined confidence interval for the estimated p-value. In this evaluation, we propose the following criteria to stop the permutation test and obtain a p-value: (i) when all permutation statistics are greater or less than the original statistic, the calculation is terminated when the probability of the event is less than the significance level, and (ii) the calculation is terminated when the confidence interval of the estimated p-value does not include a significance level. To show the effectiveness of the proposed procedure, we first evaluate the power and sample size calculations of SKAT [4], SKAT-O [5], and the proposed procedure using a genotype dataset in the SKAT R package [8]. Second, we also evaluate the type I error rate of SKAT-O and the proposed procedure using real whole genome sequencing (WGS) data from the 1000 Genomes Project (1000GP) [9]. Finally, computational experiments additionally using SNP array data downloaded from the Wellcome Trust Case Control Consortium (WTCCC) [10] and the International HapMap Project [11] show that the proposed procedure can calculate highly accurate p-values within a reasonable time. We conclude that the proposed procedure is applicable to recent sequencing and genotype imputed data with large amounts of phenotype data.
CEPSKAT extends the SKAT framework to the setting of continuous extreme phenotype samples. You can download the R package for CEPSKAT here. For Windows, download the compiled binary version instead. Consult the help files in the package for instruction and examples of usage.
coxKM (cox Kernel Machine) is an R package for conducting SNP-set association tests for right-censored survival outcomes based on kernel machine cox regression framework. coxKM is meant for common genetic variants only. coxKM tests for association between a SNP-set (made up of common variants) and a right-censored survival outcome. Software download , manual download .
gskat is a R package implements a family based association test via GEE Kernel Machine (KM) score test. It has functions to perform both burden test and SKAT test with family members as well as unrelated individuals. The package allows for both continuous and discrete traits in the association test.Software download
The current version of the R package is 0.98. Please download the source .tar.gz file or the .zip file for installation. Please download the manual PDF here. Some example files are also available for download.
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SKAT 9 Peter Heinlein is a free trial software published in the Card Games list of programs, part of Games & Entertainment.This Card Games program is available in German. It was last updated on 18 June, 2023. SKAT 9 Peter Heinlein is compatible with the following operating systems: Windows.The company that develops SKAT 9 Peter Heinlein is Peter Heinlein. The latest version released by its developer is 9.5.1. This version was rated by 47 users of our site and has an average rating of 2.6.The download we have available for SKAT 9 Peter Heinlein has a file size of 68.16 MB. Just click the green Download button above to start the downloading process. The program is listed on our website since 2014-05-13 and was downloaded 3706 times. We have already checked if the download link is safe, however for your own protection we recommend that you scan the downloaded software with your antivirus. Your antivirus may detect the SKAT 9 Peter Heinlein as malware if the download link is broken.How to install SKAT 9 Peter Heinlein on your Windows device:Click on the Download button on our website. This will start the download from the website of the developer.
Once the SKAT 9 Peter Heinlein is downloaded click on it to start the setup process (assuming you are on a desktop computer).
When the installation is finished you should be able to see and run the program.
Skat 3000 is a simulation of the card game skat and the successor of Skat 2095. There are many variants, but here is the principle: the game is usually played with three persons. Two of the players are playing against a single one, but are not allowed to communicate. Each card has a value and one suit is called "Trumpf". In every round each player loses one of his cards and the one who played the "Trumpf" card with the highest value gets all the played cards. If no "Trumpf" is played, the highest value wins. At the end each player counts the value of his cards. The goal for the single player is to get more points than the other two combined.The main feature of Skat 3000 is the integration of many local skat variants. If your favorite rule set is not included you can create it yourself with the freely adjustable rules. It also has a tutorial, animated graphics and voice acting. In comparison to Skat 2095 it features more opponents and a better playing AI. In the shareware version are several restrictions present, e.g. no adjustable rules and no save option.In 2005 there was a commercial special edition distributed which features only the official rules.
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Skat 2095 is a simulation of the card game skat and the successor of Skat 2010. There are many variants, but here is the principle: The game is usually played with three persons. Two of the players are playing against a single one but are not allowed to communicate. Each card has a value and one suit is called "Trumpf". In every round each player looses one of his card and the one which played the "Trumpf" card with the highest value gets all the played cards. If no "Trumpf" is played the highest value scores. At the end each player counts the values of his cards. The goal for the single player is to get more points than the other two combined.
The main feature of Skat 2095 is the integration of many local skat variants. If your favorite rule set is not included you can create it yourself with the freely adjustable rules. In comparison to Skat 2010 there are a few new features: A tutorial, animated graphics by German artist Uli Stein and more voice acting.
People who downloaded Skat 2095 have also downloaded:Skat 3000, Skat 2010, Sid Meier's Civilization 3, SimIsle: Missions in the Rainforest, Age of Empires, Star Trek: TNG: Birth of the Federation, Stronghold, Monopoly (1999)
Skat is played with a German 32 card deck, or Aces through 7s in all suits. After shuffling the deck, the dealer passes out the cards in the following way: Three cards to each player, two cards set aside for the skat pile, four cards to each player, and three cards to each player. At the end of the deal, every player should have ten cards. Two cards are leftover in the deck and may be picked up by the declarer.
The player left of the dealer is called the forehand. Going clockwise, the other two players are called the middlehand and rearhand. In skat, there are two stages in the auctioning process. The first stage is between the middlehand and forehand. Starting with the middlehand, players bid on how many points they can win in the round. The player who has the highest bid before the other player passes proceeds to the next stage. The next stage is a round of bidding between the previous winner and the rearhand. The player with the highest bid becomes the declarer.
When playing ramsch hand/round, this option determines who gets the skat. When disabled, this option means no one gets the skat. Last trick means the person who won the last trick gets the skat (and its points). Loser means whoever lost the round (had the most points) gets the skat (and its points) to further worsen their loss.
It can be quite annoying when an app from the App Store cannot be loaded and thus updated. The download or update is started, but only a fraction of the app is loaded after hours.Or an app like Skat cannot be installed because the download does not start even though you are connected to the internet.
If Skat is downloading very slowly, it could also be due to the size of the app itself. The progress bar gives you a slow download, but this may only appear because of the size of the app. In the event of an update, you can check in the respective app store how big the installation file is and see whether it may load for so long due to its size.
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